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- Title
Testicular seminoma after the complete remission of extragonadal yolk sac tumor : a case report.
- Authors
Kuroda, Isao; Ueno, Munehisa; Mitsuhashi, Tomoko; Nakagawa, Ken; Yanaihara, Hitoshi; Tsukamoto, Takuji; Deguchi, Nobuhiro
- Abstract
Background: Between 2% and 5% of malignant germ-cell tumors in men arise at extragonadal sites. Of extragonadal germ cell tumors, testicular carcinoma in situ (CIS) are present in 31-42% of cases, and CIS are reported to have low sensitivity to chemotherapy in spite of the various morphology and to have a high likelihood of developing into testicular tumors. A testicular biopsy may thus be highly advisable when evaluating an extragonadal germ cell tumor. Case presentation: A 36-year-old man was diagnosed as having an extragonadal nonseminomatous germ cell tumor, that was treated by cisplatin-based chemotherapy, leading to a complete remission. In the meantime, testicular tumors were not detected by means of ultrasonography. About 4 years later, a right testicular tumor was found, and orchiectomy was carried out. Microscopically, the tumor was composed of seminoma. Conclusions: We herein report a case of metachronous occurrence of an extragonadal and gonadal germ cell tumor. In the evaluation of an extragonadal germ cell tumor, a histological examination should be included since ultrasonography is not sufficient to detect CIS or minute lesions of the testis.
- Subjects
TESTICULAR cancer; GERM cell tumors; SPONTANEOUS cancer regression; ENDODERMAL sinus tumors; CANCER chemotherapy
- Publication
BMC Urology, 2004, Vol 4, p13
- ISSN
1471-2490
- Publication type
Article
- DOI
10.1186/1471-2490-4-13