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- Title
The Efficiency of the Human CD8+ T Cell Response: How Should We Quantify It, What Determines It, and Does It Matter?
- Authors
Elemans, Marjet; Basatena, Nafisa-Katrin Seich al; Asquith, Becca
- Abstract
Multidisciplinary techniques, in particular the combination of theoretical and experimental immunology, can address questions about human immunity that cannot be answered by other means. From the turnover of virus-infected cells in vivo, to rates of thymic production and HLA class I epitope prediction, theoretical techniques provide a unique insight to supplement experimental approaches. Here we present our opinion, with examples, of some of the ways in which mathematics has contributed in our field of interest: the efficiency of the human CD8+ T cell response to persistent viruses.
- Subjects
CD8 antigen; T cells; EXPERIMENTAL immunology; IMMUNITY; EPITOPES; PERSISTENT viral diseases; HLA histocompatibility antigens
- Publication
PLoS Computational Biology, 2012, Vol 8, Issue 2, p1
- ISSN
1553-734X
- Publication type
Article
- DOI
10.1371/journal.pcbi.1002381