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- Title
Four New Pregnane Steroids from Aglaia abbreviata and Their Cytotoxic Activities.
- Authors
Zhang, Feng; Zhu, Yu; Li, Qin; Cen, Juan
- Abstract
Four new pregnane steroids, aglaiasterols A-D ( 1- 4), have been isolated from the EtOH extract of stems of Aglaia abbreviata. They were identified as (3 α,5 α,17 Z)-3-hydroxypregn-17-en-16-one ( 1), (3 β,5 α,17 E)-3-hydroxypregn-17-en-16-one ( 2), (3 β,5 α,17 Z)-3-hydroxypregn-17-en-16-one ( 3), and (3 α,5 α,20 S*)-3-hydroxy-16-oxopregnan-20-yl acetate ( 4) on the basis of spectroscopic methods, including 1D- and 2D-NMR techniques. Compounds 1- 4 were evaluated for their cytotoxic activities against K562 (human leukemia), MCF-7 (human breast cancer), and KB (human oral epithelium cancer) cells, and drug-resistant cells of K562/A02, MCF-7/ADM, and KB/VCR. These isolates showed weak to moderate inhibitory effects on the growth of the tested cell lines.
- Subjects
PREGNANE; CYCLOPENTAPHENANTHRENE; STEROIDS; CHEMICAL synthesis; CHEMICAL bonds; CHEMICAL structure
- Publication
Helvetica Chimica Acta, 2016, Vol 99, Issue 1, p73
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201500228