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- Title
Kadsufolins A - D and Related Cytotoxic Lignans from Kadsura oblongifolia.
- Authors
Zehao Huang; Yan Lu; Yinan Liu; Bastow, Kenneth F.; Kuohsiung Lee; Daofeng Chen
- Abstract
Kadsufolins A-D (-, resp.), four new dibenzocyclooctane-type lignans, were isolated from the roots and stems of Kadsura oblongifolia, together with eleven known lignans. Their structures and configurations were elucidated by spectroscopic methods including 2D-NMR techniques. The compounds were also evaluated for cytotoxic activity against human tumor cell lines A549 (lung carcinoma), DU145 (prostate carcinoma), KB (epidermoid carcinoma of the nasopharynx), and HCT-8 (ileocecal carcinoma). Kadsufolin A (), kadsufolin D (), angeloylbinankadsurin A, and heteroclitin B were found to show cytotoxic activities against A549, DU145, KB and HCT-8 with GI values of 5.1-20.0 μg/ml.
- Subjects
LIGNANS; NATURAL products; KADSURA; CELL lines; LUNG cancer
- Publication
Helvetica Chimica Acta, 2011, Vol 94, Issue 3, p519
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201000259