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- Title
A Diterpenoid with a New Skeleton and Cytotoxic Terpenoids Isolated from Amentotaxus formosana.
- Authors
Huey-Jen Su; Li-Wen Wang; Chun-Nan Lin; Shiow-Hwa Day; Bai-Luh Wei; Sheng-Zehn Yang; Shen-Jeu Won
- Abstract
The new diterpenoid 6α-hydroxy-ent-kaur-16-en-15-one (1) and a diterpenoid with a new skeleton, i.e., amentotaxin BB (5), as well as three new lanostanoids, i.e., (3β,23R)-3-methoxy-24-methylenelanost-8-en-23-ol (6), (23S)-23-methoxy-24-methylenelanost-8-en-3-one (7), and (3β,24ξ)-3-methoxy-24-methyl-9,19-cyclolanostan-25-ol (8), were isolated from the bark and leaves of Amentotaxus formosana. Their structures, including the relative configurations, were elucidated from spectroscopic data. Compound 1 and a known compound, ent-kaur-16-en-15-one (2), showed potent cytotoxic effects against a number of cancer cells in vitro.
- Subjects
DITERPENES; CANCER cells; TERPENES
- Publication
Helvetica Chimica Acta, 2003, Vol 86, Issue 7, p2645
- ISSN
0018-019X
- Publication type
Article