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- Title
Synthesis and MMP-Inhibitory Activity of Gelastatin Analogues.
- Authors
Cho, Ju-Hee; Ko, Soo Y.; Oh, Eugene; Park, Jae C.; Yoo, Ji U.
- Abstract
Gelastatin A and B, isolated from culture broth of Westerdykella multispora F50733, have been reported to exhibit MMP-inhibitory activities at a sub-micromolar level. In an effort to exploit this lead, we synthesized gelastatin analogues in which the conjugated triene unit of natural gelastatins was replaced by the benzylidene group. The ( Z)-isomeric synthetic benzylidene-gelastatin exhibited MMP-inhibitory activities comparable to those reported for the natural products. Therefore, this compound appears to be a viable lead in searching for therapeutically useful MMP inhibitors.
- Publication
Helvetica Chimica Acta, 2002, Vol 85, Issue 11, p3994
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/1522-2675(200211)85:11<3994::AID-HLCA3994>3.0.CO;2-2