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- Title
Development and Study of Anxiolytic Effect of Gml-1 Tablet Dosage Form.
- Authors
Yarkova, M. A.; Blynskaya, E. V.; Yudina, D. V.; Mokrov, G. V.; Gudasheva, T. A.; Alekseev, K. V.
- Abstract
Novel pyrrolo[1,2-a]pyrazine ligands of 18-kDa translocator protein (TSPO) were synthesized at Zakusov Research Institute of Pharmacology. Pharmacological studies of drug substance N-benzyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide (GML-1) were consistent with high affinity for TSPO and significant anxiolytic activity. A finished dosage form of GML-1 drug substance was developed and exhibited pronounced anxiolytic activity after intragastric administration over a wide dose range.
- Subjects
DOSAGE forms of drugs; TRANSLOCATOR proteins; PYRAZINES
- Publication
Pharmaceutical Chemistry Journal, 2019, Vol 53, Issue 4, p342
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-019-02003-1