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- Title
Effect of nitroxyalkyl derivatives of fullerenylproline on the activity of CA-ATPase of sarcoplasmic reticulum.
- Authors
Tat'yanenko, L.; Dobrokhotova, O.; Kotel'nikova, R.; Poletayeva, D.; Mishchenko, D.; Pikhteleva, I.; Bogdanov, G.; Romanova, V.; Kotel'nikov, A.
- Abstract
The effect of nitroxyalkyl derivatives of fullerenylproline methyl ester on the enzymatic activity of Ca-ATPase of sarcoplasmic reticulum (SR) has been studied. It is shown that hybrid derivatives of C fullerene are capable of inhibiting the activity of Ca-ATPase of SR. The mononitrate inhibits the hydrolytic activity of the enzyme with K = 1.92 × 10 M; active Ca transport, with K = 3.79 × 10 M. The dinitrate inhibits ATP hydrolysis with K = 2.38 × 10 M; Ca transport, with K = 3.08 × 10 M. Fullerenylproline methyl ester does not affect the enzymatic activity of Ca-ATPase. Based on these data it is possible to predict the possible fields of application for hybrid fullerene derivatives as potential drugs.
- Subjects
PHARMACODYNAMICS; PROLINE; ALKANES; FULLERENES; ESTERS; ADENOSINE triphosphatase; SARCOPLASMIC reticulum; FUNCTIONAL groups; THERAPEUTICS
- Publication
Pharmaceutical Chemistry Journal, 2011, Vol 45, Issue 6, p329
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-011-0627-6