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- Title
Hypothermia for Perinatal Brain Hypoxia-Ischemia in Different Resource Settings: A Systematic Review.
- Authors
Galvao, Tais F.; Silva, Marcus T.; Marques, Mariana C.; de Oliveira, Nelson D.; Pereira, Mauricio G.
- Abstract
Objective: To assess the effect of hypothermia on mortality of neonates with hypoxic-ischemic encephalopathy in different economic resources settings.Methods: We searched for randomized controlled trials on MEDLINE, Embase and other databases. Duplicate reviewers selected the studies and extracted data. We calculated meta-analyses of the relative risks (RR) and 95% confidence intervals (95% CI), and used meta-regression to evaluate the gross domestic product per capita influence on hypothermia efficacy.Results: Sixteen studies were included (n = 1889); eight were conducted in lower income countries (n = 662). Hypothermia significantly reduced mortality (RR = 0.77; 95% CI: 0.65–0.92). Meta-regression revealed that hypothermia efficacy does not increase as the gross domestic product per capita rises.Conclusions: There is enough evidence to support hypothermia as the standard care for hypoxic-ischemic encephalopathy. Evidence from low-resource settings is limited, but hypothermia efficacy was not shown to be associated with better resources countries.
- Subjects
HYPOTHERMIA; SYSTEMATIC reviews; CEREBRAL anoxia; ISCHEMIA; MEDICAL care costs; NEONATAL mortality; MEDLINE
- Publication
Journal of Tropical Pediatrics, 2013, Vol 59, Issue 6, p453
- ISSN
0142-6338
- Publication type
Article
- DOI
10.1093/tropej/fmt047