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- Title
Uso de INIBIDOR de JAK2 combinado com AINE como uma proposta de tratamento para COVID-19: Uma revisão de literatura.
- Authors
Filho, Williams Alexandre Dutra; de Paiva, Camila Maria Miranda; Delgado, Vitória Helen Feliciano; de Barros Lima Lins, Uaira Maria Maria; França, Eduardo da Silva
- Abstract
The search for drugs protocols to the COVID-19 treatment had been severely studied, considering the inflammation states and the thrombotic events. Objective: Propose, through a literature review, the combined use of baricitinib and apirin for patients with moderate to severe COVID-19 disease. .METHODS: An integrative literature review was carried out on Google Search and Pub Med, analyzing observational and clinical intervention studies Results: The average mortality between the studies with the aspirin was 13.25%, it was observed a lower necessity for mechanical ventilation and rate of admission to the ICU. While the baricitinb studies had an average of 6.25%, decrease in plasma concentrations of IL-6, CRP and neutrophils and an increase in the number of lymphocytes. Conclusion: The association of these two drugs shows antiviral, anti-inflammatory and antithrombotic activity, acting on JAK2 and NF-kb simultaneously.
- Publication
Saúde Coletiva, 2021, Vol 11, Issue 64, p5814
- ISSN
1806-3365
- Publication type
Article
- DOI
10.36489/saudecoletiva.2021v11i64p5814-5821