We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Molecular profiling and treatment pattern differences between intrahepatic and extrahepatic cholangiocarcinoma.
- Authors
Spencer, Kristen; Pappas, Leontios; Baiev, Islam; Maurer, Jordan; Bocobo, Andrea Grace; Zhang, Karen; Jain, Apurva; Armas, Anaemy Danner De; Reyes, Stephanie; Le, Tri Minh; Rahma, Osama E; Stanton, Jennifer; DeLeon, Thomas T; Roth, Marc; Peters, Mary Linton B; Zhu, Andrew X; Lennerz, Jochen K; Iafrate, A John; Boyhen, Kylie; VanCott, Christine
- Abstract
Background Treatment patterns for intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC) differ, but limited studies exist comparing them. This study examines differences in molecular profiling rates and treatment patterns in these populations, focusing on use of adjuvant, liver-directed, targeted, and investigational therapies. Methods This multicenter collaboration included patients with ICC or ECC treated at 1 of 8 participating institutions. Retrospective data were collected on risk factors, pathology, treatments, and survival. Comparative statistical tests were 2-sided. Results Among 1039 patients screened, 847 patients met eligibility (ICC = 611, ECC = 236). Patients with ECC were more likely than those with ICC to present with early stage disease (53.8% vs 28.0%), undergo surgical resection (55.1% vs 29.8%), and receive adjuvant chemoradiation (36.5% vs 4.2%) (all P < .00001). However, they were less likely to undergo molecular profiling (50.3% vs 64.3%) or receive liver-directed therapy (17.9% vs 35.7%), targeted therapy (4.7% vs 18.9%), and clinical trial therapy (10.6% vs 24.8%) (all P < .001). In patients with recurrent ECC after surgery, the molecular profiling rate was 64.5%. Patients with advanced ECC had a shorter median overall survival than those with advanced ICC (11.8 vs 15.1 months; P < .001). Conclusions Patients with advanced ECC have low rates of molecular profiling, possibly in part because of insufficient tissue. They also have low rates of targeted therapy use and clinical trial enrollment. While these rates are higher in advanced ICC, the prognosis for both subtypes of cholangiocarcinoma remains poor, and a pressing need exists for new effective targeted therapies and broader access to clinical trials.
- Subjects
CHOLANGIOCARCINOMA; INVESTIGATIONAL therapies; TUMOR classification; OVERALL survival; SURGICAL excision; CLINICAL trials
- Publication
JNCI: Journal of the National Cancer Institute, 2023, Vol 115, Issue 7, p870
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/djad046