We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Importance of Increased Serum GFAP and UCH-L1 Levels in Distinguishing Large Vessel from Small Vessel Occlusion in Acute Ischemic Stroke.
- Authors
Kraljević, Ivan; Sablić, Sara; Marinović Guić, Maja; Budimir Mršić, Danijela; Štula, Ivana; Dolić, Krešimir; Benzon, Benjamin; Košta, Vana; Čaljkušić, Krešimir; Marčić, Marino; Šupe Domić, Daniela; Lovrić Kojundžić, Sanja
- Abstract
Acute ischemic stroke (AIS) is one of the leading causes of morbidity worldwide, thus, early recognition is essential to accelerate treatment. The only definite way to diagnose AIS is radiological imaging, which is limited to hospitals. However, two serum neuromarkers, glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1), have been proven as indicators of brain trauma and AIS. We aimed to investigate the potential utility of these markers in distinguishing between large vessel occlusion (LVO) and small vessel occlusion (SVO), considering differences in treatment. Sixty-nine AIS patients were included in our study and divided into LVO and SVO groups based on radiological imaging. Control group consisted of 22 participants without history of neurological disorders. Results showed differences in serum levels of both GFAP and UHC-L1 between all groups; control vs. SVO vs. LVO (GFAP: 30.19 pg/mL vs. 58.6 pg/mL vs. 321.3 pg/mL; UCH-L1: 117.7 pg/mL vs. 251.8 pg/mL vs. 573.1 pg/mL; p < 0.0001), with LVO having the highest values. Other prognostic factors of stroke severity were analyzed and did not correlate with serum biomarkers. In conclusion, a combination of GFAP and UCH-L1 could potentially be a valuable diagnostic tool for differentiating LVO and SVO in AIS patients.
- Subjects
ISCHEMIC stroke; DEUBIQUITINATING enzymes; GLIAL fibrillary acidic protein; LACUNAR stroke; BRAIN injuries
- Publication
Biomedicines, 2024, Vol 12, Issue 3, p608
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines12030608