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- Title
Effect of Clostridium butyricum on Gastrointestinal Infections.
- Authors
Ariyoshi, Tadashi; Hagihara, Mao; Takahashi, Motomichi; Mikamo, Hiroshige
- Abstract
Clostridium butyricum is a human commensal bacterium with beneficial effects including butyrate production, spore formation, increasing levels of beneficial bacteria, and inhibition of pathogenic bacteria. Owing to its preventive and ameliorative effects on gastrointestinal infections, C. butyricum MIYAIRI 588 (CBM 588) has been used as a probiotic in clinical and veterinary medicine for decades. This review summarizes the effects of C. butyricum, including CBM 588, on bacterial gastrointestinal infections. Further, the characteristics of the causative bacteria, examples of clinical and veterinary use, and mechanisms exploited in basic research are presented. C. butyricum is widely effective against Clostoridioides difficile, the causative pathogen of nosocomial infections; Helicobacter pylori, the causative pathogen of gastric cancer; and antibiotic-resistant Escherichia coli. Accordingly, its mechanism is gradually being elucidated. As C. butyricum is effective against gastrointestinal infections caused by antibiotics-induced dysbiosis, it can inhibit the transmission of antibiotic-resistant genes and maintain homeostasis of the gut microbiome. Altogether, C. butyricum is expected to be one of the antimicrobial-resistance (AMR) countermeasures for the One-health approach.
- Subjects
CLOSTRIDIUM butyricum; HELICOBACTER pylori; PATHOGENIC bacteria; GUT microbiome; NOSOCOMIAL infections; CLOSTRIDIA; CAMPYLOBACTER jejuni
- Publication
Biomedicines, 2022, Vol 10, Issue 2, p483
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines10020483