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- Title
Epithelioid leiomyosarcoma arising from the ocular region in a dog.
- Authors
Tomokazu Nagashima; Chisato Kishi; Yukino Machida; Masaki Michishita
- Abstract
A 16-year-old male mixed-breed dog presented with a mass with hemorrhage at the right conjunctiva. Five months after the initial visit, the right eye protruded and had a firm and irregular mass measuring approximately 1.00 cm in diameter with conjunctival hemorrhage. Microscopically, the mass was comprised polygonal or round tumor cells with distinct cell borders arranged in a nested and diffuse pattern. The tumor cells had round-to-oval fine hyperchromatic nuclei containing distinct multiple nucleoli and abundant eosinophilic or pale cytoplasm. Multiple giant cells were frequently observed. The mitotic index was 12.60/high power field. Extensive necrosis, hemorrhage and part of the cord-like and papillary epithelioid cells were observed in the intra-tumor tissue. Immunohistochemically, the tumor cells were positive for vimentin and α-smooth muscle actin and negative for cytokeratin, desmin and PNL2. On the other hand, the cord-like and papillary epithelioid cells were positive for vimentin, S100 and neuron-specific enolase. The tumor was diagnosed as an epithelioid leiomyosarcoma. This case considered to have occurred in the ocular region, although the ocular structure was destroyed.
- Subjects
LEIOMYOSARCOMA; DOGS; CONJUNCTIVA; ACTIN; IMMUNOHISTOCHEMISTRY
- Publication
Veterinary Research Forum, 2024, Vol 15, Issue 5, p257
- ISSN
2008-8140
- Publication type
Article
- DOI
10.30466/vrf.2024.2018820.4110