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- Title
EVALUATION OF THE TOXICOLOGICAL SAFETY OF A FREEZE-DRIED PROBIOTIC PREPARATION.
- Authors
DENKOVA, Zapryana; MURGOV, Ivan; DENKOVA, Rositsa; ENIKOVA, Rositsa
- Abstract
A combination consisting of selected probiotic strains lactobacilli and bifidobacteria from the National Bank for Industrial Microorganisms and Cell Cultures (NBIMCC), Bulgaria was developed. During their joint cultivation the strains demonstrated their ability to multiplicate, accumulating high concentrations of viable cells. The toxicogenity of the symbiotic combination was examined by testing the freeze-dryed substance, containing lactobacilli and bifidobacteria, on biological objects (white mice). Each experimental animal was injected intraperitoneally with 5.108CFU viable cells daily in the duration of 10 days. After the experimental period a post-mortem examination was conducted to analyze the safety of the substance of probiotic lactobacilli and bifidobacteria, which is the basis for the preparation of probiotic combinations. The absence of toxicogenity of the freeze-dried substance of probiotic lactobacilli and bifidobacteria is proven by the lack of any pathological changes in the health status, damages to the parenchymal organs, the peritoneum or the omentum that would otherwise indicate toxicity.
- Subjects
PROBIOTICS; FREEZE-dried foods; TOXICOLOGY; LACTOBACILLUS; BIFIDOBACTERIUM
- Publication
Food & Environment Safety, 2014, Vol 13, Issue 2, p109
- ISSN
2068-6609
- Publication type
Article