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- Title
Has the importance of GABA<sub>A</sub> presynaptic inhibition been overestimated in human motor control?
- Authors
Burke, David
- Abstract
The reflex depression was accompanied by a decrease in motoneuron firing rate, interpreted as evidence of postsynaptic inhibition of the motoneuron. Voluntary contraction biases spinal cord circuitry, and there is evidence that the contraction-associated changes are maximal when going from rest to weak contraction rather than weak to stronger contractions (Pierrot-Deseilligny & Burke, [5]). Keywords: ectopic activity; GABAA receptors; post-activation depression; presynaptic inhibition; primary afferent depolarization EN ectopic activity GABAA receptors post-activation depression presynaptic inhibition primary afferent depolarization 1699 1700 2 05/17/23 20230515 NES 230515 Spinal cord reflexes can be depressed by inhibiting the motoneuron or by decreasing the excitation by afferent inputs.
- Subjects
SPASTICITY; INHIBITORY postsynaptic potential; AMYOTROPHIC lateral sclerosis; H-reflex; MOTOR unit; SPINAL cord
- Publication
Journal of Physiology, 2023, Vol 601, Issue 10, p1699
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/JP284687