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- Title
CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET.
- Authors
CINAR KOC, Ahsen Sevde; RIZVANOGLU, Suna Sibel; ERYILMAZ, Müjde; DEMIRCI, Betül; ONDER, Alev
- Abstract
Objective: The study aimed to determine the chemical composition and antibacterial, antibiofilm, and anti-quorum sensing activities of the essential oil of Salvia absconditiflora Greuter & Burdet (an endemic species) growing wildly in Türkiye. Material and Method: The essential oil from the aerial parts of the plant was obtained by hydrodistillation (0.4%) and analyzed by GC-FID and GC-MS. In addition, the broth microdilution method was used to determine antibacterial activity. The crystal violet assay was performed for antibiofilm activity, and the reporter bacteria Chromobacterium violaceum ATCC 12472 was used in the anti-quorum sensing activity test. Result and Discussion: The major components of the essential oil were identified as 1,8-cineole (32.2%), camphor (13.6%), a-pinene (7.6%), camphene (5.5%), and viridiflorol (5.1%). The essential oil showed the best antibacterial activity against Gram-positive test bacteria, with a minimum inhibitory concentration (MIC) of 0.0078 (v/v) against Staphylococcus aureus strains. The percentage biofilm inhibition value of the essential oil was determined as 84.4%. The inhibition of violacein production by the essential oil in Chromobacterium violaceum ATCC 12472 indicated the possibility of anti-quorum sensing activity. The results of this study show that the essential oil of S. absconditiflora could be a promising alternative in fighting bacterial infections.
- Subjects
ESSENTIAL oils; CHROMOBACTERIUM violaceum; ANTIBACTERIAL agents; ENDEMIC plants; BIOACTIVE compounds; BACTERIAL disease treatment
- Publication
Journal of Faculty of Pharmacy of Ankara University / Ankara Üniversitesi Eczacilik Fakültesi Dergisi, 2024, Vol 48, Issue 2, p586
- ISSN
1015-3918
- Publication type
Article
- DOI
10.33483/jfpau.1416623