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- Title
Evaluation of the New Consensus Criteria for the Diagnosis of Primary Progressive Aphasia Using Fluorodeoxyglucose Positron Emission Tomography.
- Authors
Matias-Guiu, Jordi A.; Cabrera-Martín, Maria Nieves; García-Ramos, Rocío; Moreno-Ramos, Teresa; Valles-Salgado, Maria; Carreras, José Luis; Matias-Guiu, Jorge
- Abstract
Background: New consensus criteria have been proposed to classify primary progressive aphasia (PPA) into three variants: agrammatic, semantic, and logopenic. Some studies have subsequently addressed the usefulness of these criteria, with controversial results. We aimed to determine the correlation between the clinical diagnosis according to the new criteria and brain topography in 18F-fluorodeoxyglucose positron emission tomography (FDG-PET). Methods: Patients meeting the PPA criteria were prospectively recruited in a single center during a period of 18 months. They were clinically classified according to the new criteria and underwent FDG-PET. The cerebral metabolism of each patient was compared to a healthy control group using statistical parametric mapping. The expected variant according to the analysis of PET imaging was compared with the clinical diagnosis using the consensus criteria. Results: 32 patients were included. 90% of them fulfilled the consensus criteria and could be classified into one of the three clinical variants. The correlation with the cerebral metabolism was high: the kappa index was 0.91 in the agrammatic variant, 0.71 in the semantic variant, and 0.74 in the logopenic variant. Conclusions: A high correlation with the diagnosis obtained using FDG-PET was found. However, an overdiagnosis of the logopenic variant was observed. These results support the use of the new criteria, but some modifications or complementary studies may still be necessary. © 2014 S. Karger AG, Basel
- Subjects
DIAGNOSIS of aphasia; AGE factors in disease; APHASIA; COMPARATIVE studies; DEOXY sugars; LONGITUDINAL method; QUESTIONNAIRES; RADIOPHARMACEUTICALS; SPEECH evaluation; STATISTICS; T-test (Statistics); POSITRON emission tomography; PREDICTIVE tests; DATA analysis software; DESCRIPTIVE statistics
- Publication
Dementia & Geriatric Cognitive Disorders, 2014, Vol 38, Issue 3/4, p147
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000358233