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- Title
Response to Rivastigmine Transdermal Patch or Memantine plus Rivastigmine Patch is affected by Apolipoprotein E Genotype in Alzheimer Patients.
- Authors
Han, Hyun Jeong; Kim, Byeong C.; Lee, Jun-Young; Ryu, Seung-Ho; Na, Hae Ri; Yoon, Soo Jin; Park, Hyun Young; Shin, Joon Hyun; Cho, Soo-Jin; Yi, Hyon-Ah; Choi, Mun Seong; Heo, Jae-Hyeok; Park, Kyung Won; Kim, Kwang K.; Choi, Seong Hye
- Abstract
Background/Aims: The apolipoprotein E (APOE) genotype in response to pharmacological treatments in patients with Alzheimer's disease (AD) remains a matter of controversy. This analysis investigated the effect of the APOE genotype on the clinical response to rivastigmine transdermal patch monotherapy or memantine plus rivastigmine patch in patients with mild to moderate AD. Methods: Two hundred and six (n = 206) patients with probable AD and Mini-Mental State Examination (MMSE) scores of 10-20 were randomized to rivastigmine patch monotherapy or memantine plus rivastigmine patch for 24 weeks. Of the 206 patients with probable AD, 146 patients who consented to genetic testing for APOE were included and assessed for this subgroup study. Results: There were no significant differences on MMSE, NPI, ADAS-cog, ADCS-ADL, CDR-SB, NPI and FAB between rivastigmine patch monotherapy and memantine plus rivastigmine patch according to the APOE genotype. However, patients with moderately severe AD (MMSE ≤15) who were APOE ε4 carriers showed higher responder rates on ADCS-ADL with memantine plus rivastigmine patch compared to rivastigmine patch monotherapy. Conclusion: Moderately severe AD patients with the APOE ε4 allele may respond more favorably to memantine plus rivastigmine patch than ε4 noncarriers. Copyright © 2012 S. Karger AG, Basel
- Subjects
SOUTH Korea; THERAPEUTIC use of transdermal medication; RIVASTIGMINE; CARRIER state (Communicable diseases); ALZHEIMER'S disease; RESEARCH funding; STATISTICAL sampling; BIOPHYSICS; PROBABILITY theory; MEMANTINE; TREATMENT effectiveness; SEVERITY of illness index; LONGITUDINAL method; COMBINED modality therapy; NEUROPSYCHOLOGICAL tests; APOLIPOPROTEINS; RESEARCH; CONFIDENCE intervals; GENOTYPES; ALLELES; SCIENTIFIC apparatus &; instruments
- Publication
Dementia & Geriatric Cognitive Disorders, 2012, Vol 34, Issue 3/4, p167
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000342927