We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Monosaccharide inhibition of adherence by Pseudomonas aeruginosa to canine corneocytes.
- Authors
McEwan, Neil A.; Rème, Christophe A.; Gatto, Hugo; Nuttall, Timothy J.
- Abstract
The effect ofd-galactose,d-mannose,l-rhamnose and dextrose on the adhesion to canine corneocytes by three strains of Pseudomonas aeruginosa was studied in six healthy dogs. Canine corneocytes were collected from the inner aspect of the pinna using adhesive discs (D-Squame®). Half millimetre of bacterial suspension in phosphate-buffered saline (PBS) with or without the addition of a monosaccharide was placed over the corneocyte layer and incubated in moist chambers. Image analysis was used to quantify bacterial adherence to corneocytes. The three strains of Pseudomonas adhered well to canine corneocytes. All monosaccharides tested inhibited the adherence of Pseudomonas to canine corneocytes. The mean reduction in adhesion for individual sugars at a concentration of 0.1% was 40.2% (dextrose), 30.8% (l-rhamnose), 25.6% (d-galactose) and 19.4% (d-mannose). Whend-galactose,d-mannose andl-rhamnose were used in combination at 0.1% concentration, the mean reduction in adherence was 52.9%. The monosaccharides studied may have a potential role in the management of Pseudomonas infections in dogs.
- Subjects
MONOSACCHARIDES; PSEUDOMONAS aeruginosa; PSEUDOMONAS diseases; MANNOSE; GALACTOSE
- Publication
Veterinary Dermatology, 2008, Vol 19, Issue 4, p221
- ISSN
0959-4493
- Publication type
Article
- DOI
10.1111/j.1365-3164.2008.00678.x