We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Immunization for Children Living With HIV: A Scoping Review.
- Authors
Kampiire, Leatitia; Archary, Moherndran; Frigati, Lisa; Penazatto, Martina; Brusamento, Serena
- Abstract
Background Immunosuppression secondary to human immunodeficiency virus (HIV) increases the risk of vaccine-preventable diseases in children living with HIV (CLHIV). Although vaccines are cost-effective interventions, their efficacy, immunogenicity, safety, and persistence of post-vaccination immunity in CLHIV receiving antiretroviral therapy (ART) is unclear. We aimed at identifying existing scientific evidence on immunization of CLHIV generated in the last 10 years to identify the need for a systematic review. Methods Studies were identified using a broad search strategy applied in multiple databases. Included studies involved CLHIV aged 0-10 years and presented outcomes on safety, efficacy, effectiveness, immunogenicity, and use of booster vaccines. Results Nineteen publications were identified. There was variable immunogenicity to and efficacy of vaccines by HIV and ART status. All vaccines were safe. Conclusion The heterogeneity of available studies makes it complex to do a systematic review and meta-analysis. A more uniform approach to sampling and follow-up in future studies would make comparison and interpretation of results more robust.
- Subjects
HIV prevention; HIV infections; ONLINE information services; MEDICAL databases; POLIOMYELITIS vaccines; IMMUNIZATION; MEDICAL information storage &; retrieval systems; HAEMOPHILUS disease vaccines; DPT vaccines; SYSTEMATIC reviews; AIDS vaccines; ANTIRETROVIRAL agents; PNEUMOCOCCAL vaccines; VACCINE effectiveness; MENINGOCOCCAL vaccines; IMMUNITY; DESCRIPTIVE statistics; ROTAVIRUS vaccines; LITERATURE reviews; MEDLINE; MMR vaccines; CHILDREN
- Publication
Journal of the Pediatric Infectious Diseases Society, 2022, Vol 11, Issue 4, p159
- ISSN
2048-7193
- Publication type
Article
- DOI
10.1093/jpids/piab119