We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Randomized, comparative, double-blind study of amlodipine vs. nicardipine as a treatment of isolated systolic hypertension in the elderly.
- Authors
Mounier-Véhier, Claire; Jaboureck, Olivier; Emeriau, Jean-Paul; Bernaud, Corine; Clerson, Pierre; Carre, Alain
- Abstract
A 90-day, multicenter, randomized, double-blind, parallel-group study was conducted to compare the efficacy of amlodipine (once a day) with nicardipine (two to three times a day), in the treatment of isolated systolic hypertension (ISH) in the elderly. Patients (n = 133) aged ≥60 years, with ISH were randomized to receive either amlodipine 5 mg/day, or nicardipine 60 mg/day (titrated if necessary to 10 mg/day and 100 mg/day, respectively) for 90 days. Efficacy was assessed by measuring office blood pressure (BP), and 24-h ambulatory blood pressure monitoring (ABPM). The two treatments substantially and comparably reduced office systolic blood pressure (SBP) and pulse pressure (PP), and also produced a slight decrease in diastolic blood pressure (DBP). Amlodipine reduced SBP, as assessed by ABPM, to a significantly greater extent than nicardipine. Both treatments were well-tolerated. The sustained effect of amlodipine, compared with nicardipine, was reflected in its significantly greater antihypertensive activity, particularly during the nocturnal period, as assessed by ABPM. The study demonstrates that once a day dose of amlodipine is an effective antihypertensive treatment for elderly ISH patients.
- Subjects
AMLODIPINE; HYPERTENSION; MEDICAL care
- Publication
Fundamental & Clinical Pharmacology, 2002, Vol 16, Issue 6, p537
- ISSN
0767-3981
- Publication type
Article
- DOI
10.1046/j.1472-8206.2002.00129.x