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- Title
Putting numbers on mycobacterium activated T cell subsets.
- Authors
Ottenhoff, T. H. M.
- Abstract
This article discusses cellular immunity to intracellular pathogens. Unravelling cellular immunity to intracellular pathogens continues to be full of surprises, yielding insights that reach beyond the understanding of immunity to parasites alone. Intracellular microbes reside in phagolysosomal compartments of mononuclear phagocytes and, therefore, protection against these organisms is entirely dependent on a proper cell-mediated immune response. More recently, novel classes of T cell receptor ligands and antigen presentation molecules have entered the scene: besides 'regularly' processed peptide epitopes, T cells can also recognize non-peptide ligands such as mycobaeterial mycolic acids, lipoarabinomannan and isopentenyl-phosphate group.
- Subjects
IMMUNITY; IMMUNE response; CELLULAR immunity; LYMPHOCYTES; T cells; CELL membranes; CELL receptors; EPITOPES
- Publication
Clinical & Experimental Immunology, 1996, Vol 104, Issue 3, p381
- ISSN
0009-9104
- Publication type
Editorial
- DOI
10.1046/j.1365-2249.1996.80783.x