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- Title
Ets-1: a new player in the pathogenesis of systemic lupus erythematosus?
- Authors
Pan, H.-F.; Leng, R.-X.; Tao, J.-H.; Li, X.-P.; Ye, D.-Q.
- Abstract
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) (Ets-1) is a member of the Ets family of transcription factors that share a unique Ets DNA binding domain. They control a wide variety of cellular processes including cell proliferation and differentiation. Recently, two genome-wide association studies in systemic lupus erythematosus (SLE) independently identified genetic variants in Ets-1 associated with SLE. Interestingly, previous studies have found that Ets-1-deficient mice develop lupus-like disease characterized by high titers of IgM and IgG autoantibodies, immune complex-mediated glomerulonephritis, and local activation of complement. In addition, Ets-1 is also involved in many cellular abnormalities that are known to participate in SLE pathogenesis, such as its role in negative regulation of Th17 cell and B cell differentiation. All these findings suggest that Ets-1 may play an important role in the pathogenesis of SLE. This article will focus on current understanding of the role of Ets-1 in the physiological and pathological functions associated with SLE. It is the intention of the article to provide insights which may assist in the development of Ets-1 based approaches for the treatment of SLE.
- Subjects
SYSTEMIC lupus erythematosus; CARCINOGENESIS; DNA-binding proteins; B cell differentiation; CELL proliferation; CELL differentiation; AUTOANTIBODIES; ONCOGENES; GENETICS
- Publication
Lupus, 2011, Vol 20, Issue 3, p227
- ISSN
0961-2033
- Publication type
Opinion
- DOI
10.1177/0961203310389842