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- Title
L-Proline Catalyzed Direct Synthesis of (E)-Nitroalkenes from Aldehydes in Aqueous Medium.
- Authors
Mohanta, Rahul; Mezhubeinuo; Devi, Mandita; Bez, Ghanashyam
- Abstract
Direct synthesis of conjugated nitroalkene via Henry condensation reaction in one-pot often leads to poor conversion and yield due to the reversible nature of β-nitroalcohol intermediate which undergoes reversible reaction in the basic medium. Here we report a synthesis of β-nitroalkene employing L-proline, a bifunctional catalyst, which directs the reaction of aldehyde with nitroalkane to take a different reaction path that is devoid of β-nitroalcohol intermediate. Ready availability, low-cost, and environmental compatibility of the catalyst, use of water as a solvent, simple reaction conditions, and good to excellent yields of nitroalkenes are some of the highlights of our protocol.
- Subjects
NITROALKENES; ALDEHYDES; NITROALDOL reactions; CONDENSATION reactions; WATER use; PROLINE
- Publication
Catalysis Letters, 2023, Vol 153, Issue 10, p3003
- ISSN
1011-372X
- Publication type
Article
- DOI
10.1007/s10562-022-04228-4