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- Title
Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing.
- Authors
Hoyle, Nathaniel P.; Seinkmane, Estere; Putker, Marrit; Feeney, Kevin A.; Krogager, Toke P.; Chesham, Johanna E.; Bray, Liam K.; Thomas, Justyn M.; Dunn, Ken; Blaikley, John; O'Neill, John S.
- Abstract
The article presents a study of the role of circadian actin dynamics in the mobilization of rhythmic fibroblasts during wound healing, exploring the functional consequences of the rhythm. It demonstrates that cell-autonomous clock regulates wound healing ex vivo, in vitro and in vivo by controlling cystoskeletal dynamics through circadian regulation.
- Subjects
ACTIN; CIRCADIAN rhythms; CYTOSKELETON; FIBROBLASTS; WOUND healing; BIOLOGICAL rhythms; PHYSIOLOGY
- Publication
Science Translational Medicine, 2017, Vol 9, Issue 415, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aal2774