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- Title
Quality and quantity of T<sub>FH</sub> cells are critical for broad antibody development in SHIV<sub>AD8</sub> infection.
- Authors
Takuya Yamamoto; Lynch, Rebecca M.; Gautam, Rajeev; Matus-Nicodemos, Rodrigo; Schmidt, Stephen D.; Boswell, Kristin L.; Darko, Sam; Wong, Patrick; Zizhang Sheng; Petrovas, Constantinos; McDermott, Adrian B.; Seder, Robert A.; Keele, Brandon F.; Shapiro, Lawrence; Douek, Daniel C.; Yoshiaki Nishimura; Mascola, John R.; Martin, Malcolm A.; Koup, Richard A.
- Abstract
The article looks at a study regarding quality and quantity of T follicular helper (TFH) cells which are critical for broad antibody development in simian-humanimmunodeficiency virus AD8 infection. It mentions role of TFH during HIV-1 infection is undefined within lymph node germinal centers (GCs). It also mentions quality of Envspecific TFH cells were associated with an expansion of Env-specific immunoglobulin G–positive GC B cells and broader neutralization across HIV clades.
- Subjects
FOLLICULAR dendritic cells; T cells; SIMIAN immunodeficiency virus diseases; LYMPH nodes; IMMUNOGLOBULIN G
- Publication
Science Translational Medicine, 2015, Vol 7, Issue 298, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aab3964