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- Title
Phytochemical Screening and In vitro Cytotoxicity of Sphagnum sericeum against Human Acute Lymphoblastic leukaemia Cell Lines.
- Authors
LATIF, ELDA SURHAIDA; AWANG, NORMAH; RASLI, NUR RASYIQIN; WONG QIAO XUAN, DAPHNE; JUFERI, NOOR ESZREZAD; MOHD KAMIL, NIK NORHAZRINA NIK; HAMID, ASMAH
- Abstract
The potential of Sphagnum sericeum moss extracts as an alternative treatment for childhood acute Lymphoblastic leukaemia (ALL) was investigated in this study. Aqueous, methanol, and chloroform Sphagnum sericeum extracts were analyzed for phytochemical composition and cytotoxic effects on T-cell ALL lines (Jurkat and CCL-119). Results show that the S. sericeum aqueous extract (SSAE) yielded the highest percentage, followed by the methanol extract (SSME) and the chloroform extract (SSCE). Phytochemical analysis identified alkaloids, glycosides, and terpenoids in all extracts. SSME demonstrated significant cytotoxicity towards ALL cells, with the lowest IC50 values observed at 72 hours. Notably, SSME induced morphological changes, including blebbing and cell fragmentation after 6 h, indicative of apoptosis and cell destruction. These findings suggest SSME's potential as a natural agent for treating paediatric ALL, offering a novel approach in cancer research and contributing insights into the phytochemical compounds and cytotoxic effects of S. sericeum extracts on T-ALL cell lines.
- Subjects
LYMPHOBLASTIC leukemia; ACUTE leukemia; CYTOTOXINS; CELL lines; PEAT mosses
- Publication
Oriental Journal of Chemistry, 2024, Vol 40, Issue 2, p333
- ISSN
0970-020X
- Publication type
Article
- DOI
10.13005/ojc/400203