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- Title
Sentinel lymph node localization for oral squamous cell carcinoma using a hybrid SPECT/CT system.
- Authors
Zhang Sheng; Liu Sheng; Ou Xiao-ping; Chen Wei-liang; Chen Jing-hua; Wang Yu-bo
- Abstract
PURPOSE: To explore an accurate, available, economic method in sentinel lymph node (SLN) localization in cN0 oral squamous cell carcinoma. METHODS: Sentinel lymph nodes of twenty-five patients with oral squamous cell carcinoma without clinical lymph metastasis were investigated using planer and SPECT/CT fused lymphoscintigraphy combined with methylene blue. The results of fused images were compared with planer images for SLN mapping in cN0 oral squamous cell carcinoma; SLNs were identified according to color and fused images. Neck dissection were performed. The pathological results of SLNs were compared with that of the remaining neck dissection. RESULTS: SLNs were identified in 23 of the 25 patients using planer lymphoscintigraphy. SLNs were successfully identified in all 25 patients using SPECT/CT fused lymphoscintigraphy. Fusing images provided better anatomic definition in all SLNs. SPECT/CT fused images identified 7 SLNs that were missed on planar lymphoscintigraphy, one of the 7 nodes contained tumor metastasis. There was one false-negative case. The sensitivity was 85.7%, accuracy was 96%, and specificity of SLNs was 100%. CONCLUSIONS: SLNs mapping using a hybrid SPECT/CT system can provide additional data which can not be offered by planar lymphoscintigraphy and can reduce false-negative finding; It is regarded as an accurate, available, economical new approach in SLN radiolocalization in oral squamous cell carcinoma.
- Subjects
LYMPH nodes; GERMINAL centers; LYMPHATICS; SQUAMOUS cell carcinoma; CANCER
- Publication
China Journal of Oral & Maxillofacial Surgery, 2009, Vol 7, Issue 1, p23
- ISSN
1672-3244
- Publication type
Article