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- Title
Immunological Analysis of Acquired Factor VIII Inhibitor in a Case with Immunologic Disorder.
- Authors
Okamura, Takashi; Yamauchi, Yasuo; Fukuda, Takahiro; Suehiro, Kazuhisa; Murakawa, Masahiro; Shibuya, Tsunefumi; Nagasawa, Kohei; Harada, Mine; Niho, Yoshiyuki
- Abstract
Coagulation factor VIII inhibitor arising in a patient with autoimmune disease was immunologically analyzed. A 63-year-old man who had been diagnosed as suffering from polyarteritis nodosa was treated with prednisolone for 10 years. Severe bleeding tendency developed and coagulation studies demonstrated a high titer of inhibitor to factor VIII:C. As a result of immunological analysis, the inhibitor was found to be IgG type autoantibody having both k and λ light chains. The subclasses were IgG1 and IgG4. The inhibitor recognized the COOH-terminal light chain (72-kDa thrombin fragment) on the factor VIII molecule as an epitope. Copyright © 1991 S. Karger AG, Basel
- Publication
Acta Haematologica, 1991, Vol 85, Issue 3, p153
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000204879