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- Title
Lymphoid Blast Crisis in a Patient with Philadelphia-Chromosome-Negative Chronic Myelocytic Leukemia.
- Authors
Takahira, Hiroyuki; Shibata, Keisuke; Hirata, Jouji; Umemura, Tsukuru; Nishimura, Junji; Nawata, Hajime
- Abstract
A 24-year-old man with Philadelphia-chromosome (Ph)-negative chronic myelocytic leukemia (CML) developed lymphoid blast crisis. In the chronic phase, karyotype was normal and the clinical and hematological features were indistinguishable from those of Ph-positive CML. Rearrangement of the breakpoint cluster region (bcr) was observed. In the blast phase, blast cells showed early B-cell phenotype (CALLA +, Ia +, TdT+) with a rearranged immunoglobulin heavy-chain gene joining region (JH). By using an immuno-blotting method and antiphosphotyrosine sera, P210bcr-ab1 protein was detected. The patient responded well to vincristine and prednisolone (VP) therapy. These findings support the concept that Ph-negative bcr + CML can behave in a very similar fashion to Ph-positive CML, not only in the clinical features of the chronic phase but also in the manner of the blast crisis. Copyright © 1989 S. Karger AG, Basel
- Publication
Acta Haematologica, 1989, Vol 81, Issue 3, p155
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000205550