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- Title
Transformation in Chronic Granulocytic Leukaemia.
- Authors
Vilpo, J.A.; Klemi, P.; Lassila, O.; Schröder, J.; de la Chapelle, A.
- Abstract
A 45-year-old female developed blastic metamorphosis in chronic granulocytic leukaemia after 52 months of chronic phase. During the subsequent 6-7 months, lymphosarcomatous enlargements of various lymph nodes developed. The blast cells in lymph nodes differed morphologically from those in bone marrow and blood, being 'lymphoid' non-B, non-T, non-ALL cells. The karyotype of all metaphases from one lymph node was 47, XX, +21(Ph1+) being identical to the karyotype of medullary cells. However, the karyotype of all blasts from another lymph node was 47, XX, + mar(Ph1+). It is likely that the local micro-environment controlled the clonal differentiation of these subpopulations which had originated from the same Ph1-positive multipotent stem cell. In lymph nodes and other extramedullary sites blasts were primitive without differentiation, but a myeloid differentiation in the bone marrow was demonstrated morphologically and cytochemically. Copyright © 1979 S. Karger AG, Basel
- Publication
Acta Haematologica, 1979, Vol 62, Issue 5/6, p247
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000207582