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- Title
HIGHLIGHTS IN TUMOR METABOLOME RESEARCH: CHOLINE METABOLISM INFLUENCES INTEGRIN EXPRESSION AND SUPPORTS CELL ATTACHMENT.
- Authors
Ghallab, Ahmed
- Abstract
The article focuses on a study which demonstrate the choline metabolism strongly influences adhesion of breast and ovarian cancer cells to a fibronectin matrix. Topics discussed include EDI3, key enzyme in choline metabolism that was recently shown to cleave glycerophosphocholine (GPC) in tumor cells, choline kinase as a potential target for cancer therapy and glycerol-3-phosphate metabolized to lysophosphatidic acid, phosphatidic acid and diacylglycerol.
- Subjects
CHOLINE; BREAST cancer; OVARIAN cancer; FIBRONECTINS; CANCER treatment; GLYCEROLPHOSPHATE dehydrogenase; LYSOPHOSPHOLIPIDS
- Publication
EXCLI Journal, 2014, Vol 13, p856
- ISSN
1611-2156
- Publication type
Article