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- Title
Comparison of Response to Conventional Medical Treatment in Aspirin Sensitive and Aspirin Tolerant patients with Nasal Polyposis.
- Authors
Shokri, Sima; Nabavi, Mohammad; Arshi, Saba; Bemanian, Mohammad Hasan; Fallahpour, Morteza; Nojomi, Marzieh; dr narges eslami; Heris, Javad Ahmadian; Rekabi, Mahsa; Molatefi, Rasool; Sedighi, Gholamreza; Darabi, Kian; Torabizadeh, Mehdi; Ali aghapour; Dana, Vahid Dhobadi
- Abstract
Objective: Nasal Polyposis is a chronic and recurrent disease. Among patients with nasal polyposis 15% are aspirin sensitive. In parallel with increased disease severity, the prevalence of aspirin sensitivity increases. An oral aspirin challenge is necessary for Diagnosis. Aspirin challenge testing is difficult and time consuming, adverse reactions of aspirin are dose dependent and during aspirin challenge high doses of aspirin are administered, on the other hand aspirin desensitization is a specific treatment for patients with nasal polyposis and aspirin sensitivity. Therefore, it is necessary to find criteria to select patients with high probability of aspirin sensitivity for aspirin challenge testing. This study is done to compare aspirin sensitive and aspirin tolerant patients with nasal polyposis, according to response to standard treatment. SNOT22 scores were compared before and after treatment to evaluate response to treatment. Material and Methods: The diagnosis of nasal polyposis is made by CT scan. Patients were included in order, until the sample size was fulfilled. SNOT22 questionnaire was used for evaluation of severity of symptoms before and three months after standard treatment. Results: In this study, 78 patients (25 males and 53 females) with the average age of 41/56±11/74 years (18-63) were included. Aspirin challenge test was positive in 29 patients (37/2%). SNOT22 scores before treatment in aspirin sensitive and aspirin tolerant patients were 52/97±17/73 and 47/04±18/30 respectively and after treatment were 27/41±16/61 and 24/88±16/72 respectively which are not significant (p=0.518). Conclusion: There is no significant difference between two groups in SNOT22 scores before and after treatment. According to this study, the only factor that could predict aspirin sensitivity is the history of recurrent reactions to NSAIDs, especially to different kinds of NSAIDs.
- Subjects
ASPIRIN; IMMUNOLOGIC diseases; THERAPEUTICS
- Publication
Iranian Journal of Allergy, Asthma & Immunology, 2018, Vol 17, p117
- ISSN
1735-1502
- Publication type
Abstract