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- Title
Coats Disease: Clinical Features and Outcomes by Age Category in 351 Cases.
- Authors
Dalvin, Lauren A.; Udyaver, Sanika; Lim, Li-Anne S.; Mazloumi, Mehdi; Atalay, Hatice T.; Khoo, Chloe T. L.; Shields, Carol L.
- Abstract
Purpose: To investigate features and outcomes of Coats disease by patient age. Methods: Patients with Coats disease from 1973 to 2018 were evaluated based on age category at presentation (3 years or younger vs older than 3 to 10 years vs older than 10 years). Results: There were 351 eyes of 351 patients with Coats disease diagnosed (2 vs 6 vs 27 years, There were 351 eyes of 351 patients with Coats disease diagnosed (2 vs 6 vs 27 years, P <.001). The youngest age group had more referral diagnoses of retinoblastoma (29% vs 15% vs 0%, P <.001), worse presenting visual acuity (< 20/200: 80% vs 67% vs 31%, P <.001), more advanced Coats disease stage (stage 3B: 65% vs 38% vs 10%, P <.001), and greater clock-hour extent of telangiectasia (7 vs 5 vs 4, P <.001), light bulb aneurysms (7 vs 4 vs 3, P <.001), exudation (10 vs 7 vs 5, P <.001), and subretinal fluid (10 vs 7 vs 4, P <.001). The oldest patients received a greater total number of treatments (3.3 vs 3.1 vs 4.4, P =.04), with more argon laser photocoagulation (37% vs 52% vs 73%, P <.001) and intravitreal anti-vascular endothelial growth factor (6% vs 9% vs 23%, P <.002) and less cryotherapy (74% vs 84% vs 58%, P <.001). At mean follow-up (70 vs 65 vs 38 months, P =.02), the youngest patients had poorer visual acuity outcome (< 20/200: 83% vs 64% vs 39%, P <.001), had less disease resolution (43% vs 65% vs 62%, P =.01), and were more likely to ultimately require enucleation (22% vs 10% vs 6%, P =.01). Conclusions: Younger patients (3 years or younger) with Coats disease present with worse visual acuity and more advanced disease stage, and are more likely to require ultimate enucleation. [[J Pediatr Ophthalmol Strabismus. 2019;56(5):288–296.]
- Subjects
ENDOTHELIAL growth factors; VISUAL acuity; LASER photocoagulation; AGE groups
- Publication
Journal of Pediatric Ophthalmology & Strabismus, 2019, Vol 56, Issue 5, p288
- ISSN
0191-3913
- Publication type
Article
- DOI
10.3928/01913913-20190716-01