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- Title
Neurocognitive dysfunction and brain FDG-PET/CT findings in HIV-infected hemophilia patients and HIV-infected non-hemophilia patients.
- Authors
Imai, Koubun; Kimura, Sota; Kiryu, Yoko; Watanabe, Aki; Kinai, Ei; Oka, Shinichi; Kikuchi, Yoshimi; Kimura, Satoshi; Ogata, Mikiko; Takano, Misao; Minamimoto, Ryogo; Hotta, Masatoshi; Yokoyama, Kota; Noguchi, Tomoyuki; Komatsu, Kensuke
- Abstract
This single-institution cross-sectional study aimed to grasp the prevalence and features of neurocognitive dysfunction in HIV-infected hemophilia patients in Japan. We conducted neuropsychological tests and medical examinations in 56 HIV-infected hemophilia patients who received outpatient treatment at the AIDS Clinical Center, National Center for Global Health and Medicine. A total of 388 HIV-infected non-hemophilia patients who received outpatient treatment at the same institution were included as a control group. To investigate sites responsible for neurocognitive dysfunction in HIV-infected hemophilia patients using brain FDG-PET/CT scans, the accumulation of FDG in each brain region was compared. Approximately 50% of HIV-infected hemophilia patients had neurocognitive dysfunction. The prevalence of asymptomatic neurocognitive impairment was high (34%). Neurocognitive dysfunction was associated with educational level in HIV-infected hemophilia patients. In the symptomatic group, hemophilic arthropathy and history of cerebrovascular disorders were associated with neurocognitive dysfunction. Left temporal lobe function was reduced in the symptomatic group.
- Subjects
JAPAN; HEMOPHILIACS; NEUROCYSTICERCOSIS; HIV-positive persons; CEREBROVASCULAR disease; NEUROPSYCHOLOGICAL tests; TEMPORAL lobe
- Publication
PLoS ONE, 2020, Vol 15, Issue 3, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0230292