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- Title
No difference in follow-up estimated glomerular filtration rate between hypertensive and matched nonhypertensive kidney donors.
- Authors
Eun Hye Yang; Sung Shin; Young Hoon Kim; In Gab Jeong; Bumsik Hong; Chung Hee Baek; Hyosang Kim; Soon Bae Kim
- Abstract
Background: According to current guidelines, kidney donor candidates with controlled hypertension using 1 or 2 antihypertensive drugs may be considered as donor. However, this recommendation is based on the study that antihypertensive drug was initiated in mainly "after donor registration" and this may be white-coat hypertension because of donation-related anxiety. We compared the follow-up eGFR between kidney donors with preexisting hypertension and matched nonhypertensive donors. Methods: This single-center retrospective study classified 97 living hypertensive donors previously receiving antihypertensive drugs into two groups: 1 drug group (61 donors) and 2 drugs group (36 donors). We compared the follow-up eGFR between each donor previously receiving antihypertensive drugs and three matched nonhypertensive donors in terms of age, sex, and follow-up duration. Results: At a mean (range) of 51 months (12-214) in the 1 drug group, and 54 months (12-175) in the 2 drugs group after donation, there was no significant difference in follow-up eGFR between hypertensive donors previously receiving antihypertensive drugs and matched controls in each group and in total donors. There was no difference in the incidence of the patients with follow-up eGFR < 45 mL/min/m² in each group and their matched controls. Multiple linear regression analysis showed that baseline eGFR was the only independent predictor for the final follow-up eGFR in the total donors. Conclusion: Our results support the current guidelines that donor candidates with controlled hypertension using 1 or 2 antihypertensive drugs may be considered as donors, and may increase the strength of this recommendation.
- Subjects
GLOMERULAR filtration rate; ANTIHYPERTENSIVE agents; RENOVASCULAR hypertension; HYPERTENSION; MULTIPLE regression analysis; KIDNEYS
- Publication
Nefrologia, 2024, Vol 44, Issue 1, p32
- ISSN
0211-6995
- Publication type
Article
- DOI
10.1016/j.nefroe.2022.11.022