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- Title
Efecto del micofenolato de mofetilo y azatioprina sobre la hiperplasia gingival asociada al uso de ciclosporina A en pacientes con trasplante renal.
- Authors
de la Rosa García, E.; Mondragón Padilla, A.
- Abstract
Abstract Aim: To assess gingival overgrowth prevalence and severity in a group of kidney transplant (KT) patients, and analyze the effect of immunosuppressor drugs Cyclosporin A (CsA), Tacrolimus (Tac), Sirolimus (Siro), Azathioprine (Aza) and Mofetil Mycophenolate on this complication. Methods: Gingival overgrowth presence and severity was classified, and the impact of immunosuppressor drugs, age, oral hygiene, verapamil and nifedipine on this condition was analyzed by multiple logistic regression. Results: 172 KT pts. were examined; 137 used CsA, 25 Tac, 6 Sirolimus, 107 Aza and 56 MMF. Gingival overgrowth prevalence was 59.1% on CsA, 12.0% on Tac, and 16.7% on Sirolimus. CsA odds ratio (OR) 15.2, age <45 OR 5.6, and poor oral hygiene OR 3.2, increased, and Aza OR 0.05 and MMF OR 0.03, decreased GO prevalence. Conclusions: Aza and MMF effect was a significant protection against GO prevalence in this group of KT patients.
- Subjects
GINGIVAL hyperplasia; KIDNEY transplant patients; PHARMACODYNAMICS; ORAL hygiene; VERAPAMIL; NIFEDIPINE; LOGISTIC regression analysis
- Publication
Nefrologia, 2009, Vol 29, Issue 5, p474
- ISSN
0211-6995
- Publication type
Article