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- Title
The Effect of Clonidine Premedication on Hemodynamic Changes Following Tracheal Intubation and Co<sub>2</sub> Gas Insufflation and Postoperative Shivering In Patients Undergoing Laparoscopic Cholecystectomy; a Randomized Clinical Trial.
- Authors
Entezariasl, Masood; Isazadehfar, Khatereh; Raesi, Maryam
- Abstract
Background: Laparoscopic cholecystectomy is a proper treatment for cholecystitis but the Carbon dioxide gas which is used in surgery stimulates the sympathetic system and causes hemodynamic changes and postoperative shivering in patients undergoing operations. This study was conducted to evaluate the effects of clonidine on reducing hemodynamic changes during tracheal intubation and Carbon dioxide gas insufflation and postoperative shivering in patients undergoing laparoscopic cholecystectomy. Material and Methods: This prospective, randomized, triple-blind clinical trial was conducted on 60 patients between the 18-70 years-old age group, who were candidates of laparoscopic cholecystectomy surgery. The patients randomized into two groups (30 patients received 150 µg oral clonidine) and 30 patients received 100 mg oral Vitamin C). Heart rate and mean arterial pressure of patients were recorded before anesthesia, before and after laryngoscopy, before and after Carbon dioxide gas insufflation. Data were analyzed using Chi-2, student t-test, and analysis of variance by repeated measure considering at a significant level less than 0.05. Results: The findings of this study showed that both heart rate and mean arterial pressure in clonidine group after tracheal intubation and Carbon dioxide gas insufflation were lower than patients in the placebo group, but there was not any statistically significant difference between the two groups (p>0.05) and also postoperative shivering was not different in groups. There was no significant statistical difference in postoperative shivering between the two groups (p>0.05). Conclusion: Using 150 µg oral clonidine as a cheap and affordable premedication in patients undergoing laparoscopic cholecystectomy improves hemodynamic stability during operation.
- Subjects
DRUG efficacy; ORAL drug administration; INTUBATION; LAPAROSCOPIC surgery; SURGICAL complications; VITAMIN C; ARTERIAL pressure; CHOLECYSTECTOMY; INSUFFLATION; SHIVERING; RANDOMIZED controlled trials; COMPARATIVE studies; CARBON dioxide; HEART beat; CLONIDINE; HEMODYNAMICS; PNEUMOPERITONEUM; PREANESTHETIC medication; TRACHEA intubation; PULMONARY gas exchange; EVALUATION
- Publication
International Tinnitus Journal, 2023, Vol 27, Issue 2, p174
- ISSN
0946-5448
- Publication type
Article
- DOI
10.5935/0946-5448.20230027