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- Title
Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice.
- Authors
de Vasconcelos, Danielle Ingrid Bezerra; Leite, Jacqueline Alves; Carneiro, Luciana Teles; Piuvezam, Márcia Regina; de Lima, Maria Raquel Vitorino; de Morais, Liana Clébia Lima; Rumjanek, Vivian Mary; Rodrigues-Mascarenhas, Sandra
- Abstract
Ouabain, an inhibitor of the Na+/K+-ATPase pump, was identified as an endogenous substance of human plasma. Ouabain has been studied for its ability to interfere with various regulatory mechanisms. Despite the studies portraying the ability of ouabain to modulate the immune response, little is known about the effect of this substance on the inflammatory process. The aim of this work was to study the effects triggered by ouabain on inflammation and nociceptive models. Ouabain produced a reduction in the mouse paw edema induced by carrageenan, compound 48/80 and zymosan. This anti-inflammatory potential might be related to the inhibition of prostaglandin E2, bradykinin, and mast-cell degranulation but not to histamine. Ouabain also modulated the inflammation induced by concanavalin A by inhibiting cell migration. Besides that, ouabain presented antinociceptive activity. Taken these data together, this work demonstrated, for the first time, that ouabain presented in vivo analgesic and anti-inflammatory effects.
- Subjects
ANTI-inflammatory agents; DRUG activation; ENZYME activation; ADENOSINE triphosphatase; LABORATORY mice; IMMUNOREGULATION; HISTAMINE; CELL migration; PHARMACODYNAMICS
- Publication
Mediators of Inflammation, 2011, Vol 2011, p1
- ISSN
0962-9351
- Publication type
Article
- DOI
10.1155/2011/912925