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- Title
Serum TNF-Alpha Level Predicts Nonproliferative Diabetic Retinopathy in Children.
- Authors
Zorena, Katarzyna; Myśiwska, Jolanta; Myśliwiec, Małgorzata; Balcerska, Anna; Hak, Łukasz; Lipowski, Paweł; RaczyĔska, Krystyna
- Abstract
The aim of this study was identification of the immunologic markers of the damage to the eye apparatus at early stages of diabetes mellitus (DM) type I children. One hundred and eleven children with DM type I were divided into two groups: those with nonproliferative diabetic retinopathy (NPDR) and without retinopathy. All the children had their daily urine albumin excretion, HbA1c, C-peptide measured, 24-hour blood pressure monitoring, and ophthalmologic examination. Levels of TNF-α, IL-6, and IL-12 in serum were measured by ELISA tests (Quantikine High Sensitivity Human by R&D Systems, Minneapolis, Minn, USA). The NPDR children demonstrated a significantly longer duration of the disease in addition to higher HbA1c, albumin excretion rate, C-reactive protein, systolic blood pressure, as well as TNF-α and IL-6 levels than those without retinopathy. The logistic regression revealed that the risk of NPDR was strongly dependent on TNF-α [(OR 4.01 ; 95%C1 2.01-7.96)]. TNF-α appears to be the most significant predictor among the analyzed parameters of damage to the eye apparatus. The early introduction of the TNF-α antagonists to the treatment of young patients with DM type 1 who show high serum activity of the TNF-α may prevent them from development of diabetic retinopathy.
- Subjects
TUMOR necrosis factors; SERUM; DIABETIC retinopathy; CHILDREN; BIOMARKERS; THERAPEUTICS
- Publication
Mediators of Inflammation, 2007, Vol 2007, Issue 1, p1
- ISSN
0962-9351
- Publication type
Article
- DOI
10.1155/2007/92196