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- Title
Humanized HO-1 BAC transgenic mice: a new model for the study of HO-1 gene regulation.
- Authors
Salom, Miguel G; Bonacasa, Bárbara
- Abstract
Heme oxygenase-1 (HO-1) is a ubiquitous inducible stress-response enzyme that plays a central role in tissue homeostasis, in protection against oxidative stress, and in the pathogenesis of disease. Kim et al. report a novel transgenic mouse that lacks the endogenous HO-1 gene but contains the human HO-1 gene with all its regulatory elements. These transgenic animals overexpress HO-1 in basal conditions but maintain HO-1 inducibility, protecting the kidney against glycerol- and cisplatin-induced nephrotoxicity.
- Subjects
HEME oxygenase; HOMEOSTASIS; TRANSGENIC mice; NEPHROTOXICOLOGY; DISEASES
- Publication
Kidney International, 2012, Vol 82, Issue 3, p253
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2012.149