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- Title
Selective changes in single cell GABA<sub>A</sub> receptor subunit expression and function in temporal lobe epilepsy.
- Authors
Brooks-Kayal, Amy R.; Shumate, Melissa D.; Jin, Hong; Rikhter, Tatiana Y.; Coulter, Douglas A.
- Abstract
Temporal lobe epilepsy is the most prevalent seizure disorder in adults. Compromised inhibitory neurotransmitter function in the hippocampus contributes to the hyperexcitability generating this condition, but the underlying molecular mechanisms are unknown. Combining patch-clamp recording and single-cell mRNA amplification (aRNA) techniques in single dentate granule cells, we demonstrate that expression of GABAA receptor subunit mRNAs is substantially altered in neurons from epileptic rats. These changes in gene expression precede epilepsy onset by weeks and correlate with profound alterations in receptor function, indicating that aberrant GABAA receptor expression and function has an essential role in the process of epileptogenesis.
- Subjects
TEMPORAL lobe epilepsy; GABA receptors; MESSENGER RNA
- Publication
Nature Medicine, 1998, Vol 4, Issue 10, p1166
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/2661