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- Title
The application of pregelatinized starch extracted from [Artocarpus altilis (Parkinson) Fosberg] (Breadfruit) as a direct compression binder in tablets.
- Authors
Rodney, Shawntae Y.; Riley, Cliff K.; Adebayo, Amusa S.
- Abstract
Direct compression is the preferred method of manufacturing tablets. However, native starch, commonly used as disintegrant, binder and/or filler, tends to possess poor intrinsic compressibility. This makes it less suitable as a direct compression ingredient. With physical and chemical modifications, key physical properties of native starch may be altered, enabling the extension of its utility. Breadfruit provides a cheap source of high quality native starch. Controlled heating at 65 °C was applied to an aqueous suspension of native breadfruit starch (NBS) to produce pregelatinized breadfruit starch (PBS). The fundamental and derived properties as well as compactibility of PBS were evaluated with metronidazole, a drug of poor inherent compressibility, as a model drug active ingredient. The crushing strength, friability, disintegration time and dissolution profiles of metronidazole tablets were used to assess the effect of PBS as a direct compression binder at 20% concentration. Significant (p<0.05) differences between the fundamental and derived properties of NBS and PBS were observed. Further, the compression characteristics of NBS, PBS, native corn starch (NCS) and commercial pregelatinized starch (CPS) were compared by assessing the crushing strength of their compacts compressed from 9.8 to 39.2 kN. Compact hardness increased in the order NCS<NBS<PBS<CPS. Assessment of the strength of the compacts made after varying compression and lubricant mixing times revealed that NBS and PBS showed plastic deformation, while NCS and CPS exhibited more elastic deformation. Metronidazole tablets containing PBS binder had a mean crushing strength and friability of 75.8 N and 1.62%, respectively, while those containing CPS binder had a mean crushing strength and friability of 55.2 N and 3.71%, respectively. Disintegration times were 108 and 58 seconds with PBS and CPS as binders, respectively. Peak dissolution (96%) occurred within 30 minutes with CPS binder while peak dissolution (91%) occurred within 10 minutes with PBS binder. Both binders met Pharmacopoeia requirements for immediate release tablets, suggesting that PBS may be substituted for CPS.
- Subjects
DRUG tablets; SOLID dosage forms; BREADFRUIT; BINDING agents; DRUG factories; COMPACTING; STARCH in medicine; STARCH content of plants
- Publication
Tropical Agriculture, 2016, Vol 93, p182
- ISSN
0041-3216
- Publication type
Article