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- Title
Dose-dependent effects of strontium on bone of chronic renal failure rats.
- Authors
Schrooten, Iris; Behets, Geert J.S.; Cabrera, Walter E.; Vercauteren, Sven R.; Lamberts, Ludwig V.; Verberckmoes, Steven C.; Bervoets, An J.; Dams, Geert; Goodman, William G.; De Broe, Marc E.; D'Haese, Patrick C.
- Abstract
Dose-dependent effects of strontium on bone of chronic renal failure rats. Background. We previously reported on increased bone strontium (Sr) levels in dialysis patients with osteomalacia versus those presenting other types of renal osteodystrophy. A causal role of strontium in the development of osteomalacia was established in a chronic renal failure (CRF) rat model. Methods. In the present study we investigated whether the effect of Sr on bone was related to dosage. Four groups of CRF rats were studied: a control group (control-CFR; N = 6) not receiving strontium and three groups of animals loaded orally with Sr during 18 weeks by adding the element as the SrCl2 · H2 0 compound to the drinking water at concentrations of 0.03 g/100mL (Sr-30; N = 6), 0.075 g/100mL (Sr-75; N = 6), or 0.15 g/100mL (Sr-150; N = 6) respectively. A fifth group consisting of seven animals with intact renal function (control-NRF), not receiving Sr served as controls for the effect of CRF on bone histology. Results. As compared to the control-NRF and control-CRF groups, Sr administration resulted in a dose-dependent increase in bone and serum Sr levels. No difference in body weight and biochemical serum and urinary parameters [i.e., calcium (Ca), phosphorus (P), and creatinine] was noted between the various CRF groups. At sacrifice, intact parathyroid hormone (iPTH) levels of CRF groups were significantly (P < 0.05) higher than the values measured in the control-NRF group indicating the development of hyperparathyroidism secondary to the installation of the CRF. This is further supported by the differences in bone histomorphometry between the control-CRF and control-NRF animals, which, respectively, showed an increased amount of osteoid (mean ± SEM 3.4 ± 1.2% vs. 0.37 ± 0.14%, P < 0.05) in combination with a distinct osteoblastic activity (35 ± 11% vs. <2%, P < 0.05) and an increased bone formation rate [(BFR), 677 ± 177...
- Subjects
STRONTIUM; CHRONIC kidney failure; BONES
- Publication
Kidney International, 2003, Vol 63, Issue 3, p927
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1046/j.1523-1755.2003.00809.x