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- Title
AGGRESSIVE TREATMENT STRATEGIES TO OPTIMIZE PATIENT OUTCOMES.
- Authors
Clancy, John Paul
- Abstract
The significant strides made in the understanding of cystic fibrosis (CF) and the availability of multiple therapies have dramatically improved patient outcomes, but these advances have also led to new challenges, particularly in regard to treatment selection for pulmonary manifestations of CF. This article reviews current, evidence- based treatment strategies, with a focus on recommendations from recently developed CF pulmonary guidelines and emerging trends in Pseudomonas infections. Inhaled antimicrobials targeting Pseudomonas aeruginosa and agents that aid in mucociliary clearance are mainstays in the management of CF lung disease, with antiinflammatory agents also considered important in stabilizing lung function. Also discussed are future strategies, including new classes of nebulized antibiotics, dry powder inhalation delivery systems, and use of antibiotics based on biofilm susceptibility testing.
- Subjects
CYSTIC fibrosis; LUNG disease treatment; HEALTH outcome assessment; ANTI-infective agents; PSEUDOMONAS aeruginosa; ANTI-inflammatory agents
- Publication
Johns Hopkins Advanced Studies in Medicine, 2009, Vol 9, Issue 1, p8
- ISSN
1530-3004
- Publication type
Article