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- Title
Smallpox vaccine–induced antibodies are necessary and sufficient for protection against monkeypox virus.
- Authors
Edghill-Smith, Yvette; Golding, Hana; Manischewitz, Jody; King, Lisa R.; Scott, Dorothy; Bray, Mike; Nalca, Aysegul; Hooper, Jay W.; Whitehouse, Chris A.; Schmitz, Joern E.; Reimann, Keith A.; Franchini, Genoveffa
- Abstract
Vaccination with live vaccinia virus affords long-lasting protection against variola virus, the agent of smallpox. Its mode of protection in humans, however, has not been clearly defined. Here we report that vaccinia-specific B-cell responses are essential for protection of macaques from monkeypox virus, a variola virus ortholog. Antibody-mediated depletion of B cells, but not CD4+ or CD8+ T cells, abrogated vaccine-induced protection from a lethal intravenous challenge with monkeypox virus. In addition, passive transfer of human vaccinia-neutralizing antibodies protected nonimmunized macaques from severe disease. Thus, vaccines able to induce long-lasting protective antibody responses may constitute realistic alternatives to the currently available smallpox vaccine (Dryvax).
- Subjects
VACCINATION; VACCINIA; SMALLPOX; B cells; MONKEYPOX virus
- Publication
Nature Medicine, 2005, Vol 11, Issue 7, p740
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm1261