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- Title
The pharmacologic basis of high dose chemotherapy with haematopoietic stem cell support for solid tumours.
- Authors
Porrata, L F; Adjei, A A
- Abstract
The theoretical basis of high dose chemotherapy with haematopoietic stem cell support (HDT) for solid tumours is the presumption of a linear, steep dose-response relationship for chemotherapy conditioning agents. We review preclinical pharmacologic studies evaluating steep dose-response relationships for different chemotherapeutic agents, identified through a MED-LINE and CANCER-LIT search of the English medical literature from January 1966 to December 1999. Only BCNU, melphalan, nitrogen mustard, and the combination of thiotepa and cyclophosphamide demonstrated steep dose-response relationships over a wide dose-range. The pharmacologic evidence for the use of other antineoplastic agents for HDT in solid tumours is non-existent. More preclinical studies are needed for a rational development of this therapeutic approach for solid tumours.
- Subjects
DRUG therapy; DOSE-response relationship in biochemistry
- Publication
British Journal of Cancer, 2001, Vol 85, Issue 4, p484
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1054/bjoc.2001.1970