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- Title
Research Directions in Genetic Predispositions to Stevens–Johnson Syndrome / Toxic Epidermal Necrolysis.
- Authors
Manolio, Teri A.; Hutter, Carolyn M.; Avigan, Mark; Cibotti, Ricardo; Davis, Robert L.; Denny, Joshua C.; Grenade, Lois La; Wheatley, Lisa M.; Carrington, Mary N.; Chantratita, Wasun; Chung, Wen‐hung; Dalton, Andrea D.; Hung, Shuen‐iu; Lee, Ming Ta Michael; Leeder, J. Steven; Lertora, Juan J. L.; Mahasirimongkol, Surakameth; Mcleod, Howard L.; Mockenhaupt, Maja; Pacanowski, Michael
- Abstract
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is one of the most devastating of adverse drug reactions (ADRs) and was, until recently, essentially unpredictable. With the discovery of several risk alleles for drug‐induced SJS/TEN and the demonstration of effectiveness of screening in reducing incidence, the stage is set for implementation of preventive strategies in populations at risk. Yet much remains to be learned about this potentially fatal complication of commonly used drugs.
- Subjects
STEVENS-Johnson Syndrome; GENOMICS; TOXIC epidermal necrolysis; DRUG-induced abnormalities; DRUG side effects; GENETICS; PREVENTION; THERAPEUTICS
- Publication
Clinical Pharmacology & Therapeutics, 2018, Vol 103, Issue 3, p390
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1002/cpt.890