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- Title
The Gas6/TAM System and Multiple Sclerosis.
- Authors
Bellan, Mattia; Pirisi, Mario; Sainaghi, Pier Paolo
- Abstract
Growth arrest specific 6 (Gas6) is a multimodular circulating protein, the biological actions of which are mediated by the interaction with three transmembrane tyrosine kinase receptors: Tyro3, Axl, and MerTK, collectively named TAM. Over the last few decades, many progresses have been done in the understanding of the biological activities of this highly pleiotropic system, which plays a role in the regulation of immune response, inflammation, coagulation, cell growth, and clearance of apoptotic bodies. Recent findings have further related Gas6 and TAM receptors to neuroinflammation in general and, specifically, to multiple sclerosis (MS). In this paper, we review the biology of the Gas6/TAM system and the current evidence supporting its potential role in the pathogenesis of MS.
- Subjects
GADD45 proteins; GENETICS of multiple sclerosis; PROTEIN-tyrosine kinases; PROTEIN receptors; IMMUNOREGULATION; INFLAMMATION; REGULATION of cell growth; APOPTOTIC bodies; GENETICS
- Publication
International Journal of Molecular Sciences, 2016, Vol 17, Issue 11, p1807
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms17111807